Pritam Kumar Panda

Development and internal validation of an EHR machine learning model for clinical deterioration in ICU linked inpatients

Abstract Early warning scores for inpatient deterioration rely predominantly on contemporaneous vital signs and may not incorporate broader electronic health record (EHR) information. We developed and internally validated a multi-domain EHR machine-learning model using MIMIC-IV v...

Alchemical Free Energy Perturbation Predicts Relative Binding Affinities of Propofol Analogs and Etomidate Stereoisomers at the GABAAR

Abstract General anesthetics such as propofol and etomidate exert their clinical effects primarily through positive allosteric modulation of γ-aminobutyric acid type A receptors (GABAAR). Despite decades of research, the quantitative structure–activity relationships governing ane...