Prashant Ramesh Tembhare

Process Characterization and Determinants of CD3⁺ Cell Yield During Autologous Leukapheresis for CAR-T Cell Manufacturing: A Single-Centre Experience from Western India

Background Chimeric Antigen Receptor T-cell ( CAR T-cell) therapy is a promising treatment option for patients with refractory or relapsed B-cell malignancies. The success of this therapy depends on the efficient collection of lymphocytes (CD3 + T cells) through apheresis. This s...

Concurrent ETV6::ABL1 and BCR::ABL1 in a rare case of chronic myeloid leukemia: a paradox of imatinib resistance and indolent clinical course

Abstract Chronic myeloid leukaemia (CML) is characterized by the presence of BCR::ABL1 showing favorable response to imatinib therapy. Complex rearrangements in CML are indicative of clonal evolution and often associated with disease progression and poor response to therapy. Cyto...