Ponnusamy Pon Sathieshkumar

Coupling Luciferase Activation and Bioluminescence Resonance Energy Transfer Enables High-Contrast Red-Window Calcium Imaging

Abstract Genetically encoded bioluminescent calcium indicators enable excitation-free imaging of Ca2+ dynamics with low background and without excitation-associated photobleaching. However, many exhibit lower dynamic ranges than their fluorescent counterparts, motivating the deve...