Polina Teterina

Allosteric Communication in the Tubulin Dimer Revealed through Molecular Dynamics and Network Analysis

Abstract Microtubules are dynamic polymers essential for intracellular organization, with basic constituents being αβ-tubulin dimers. Microtubule growth and shrinkage is tightly regulated by GTP hydrolysis in β-tubulin, yet how the information about the bound nucleotide propagate...