Piotr Rzepecki

NDM-Producing Klebsiella pneumoniae Bloodstream Infection Increases Mortality and Impairs Hematopoietic Recovery in Acute Leukemia

Background: Bloodstream infections (BSIs) remain among the most serious complications of intensive chemotherapy for acute leukemia. Infections caused by New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae are associated with limited therapeutic options and poor pr...

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...