Ping Xie

Mechanisms of Stability of the Metaphase Spindle and Associated Proteins Regulating Microtubule Flux

Abstract How the metaphase spindle in higher eukaryotes maintains stability in the presence of poleward microtubule (MT) flux is a confusing issue. Here, we present a model for the spindle by incorporating augmin-mediated MT connections and MT crosslinking by NuMA proteins. On th...