Piers St. Onge

Deprotonation and Alkylation of Weakly Acidic C(sp 3 )─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert ‐Butoxide

ABSTRACT The direct deprotonation of weakly acidic C(sp 3 )─H bonds remains a fundamental strategy for generating carbon nucleophiles, but typically requires strong bases, cryogenic conditions, and stepwise protocols. A general method enabling single‐step deprotonation and alkyla...

Deprotonation and Alkylation of Weakly Acidic C(sp 3 )─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert ‐Butoxide

ABSTRACT The direct deprotonation of weakly acidic C(sp 3 )─H bonds remains a fundamental strategy for generating carbon nucleophiles, but typically requires strong bases, cryogenic conditions, and stepwise protocols. A general method enabling single‐step deprotonation and alkyla...