Pier Selenica

DUSP4 overexpression is associated with MAPK pathway alterations in low-grade serous ovarian cancer

MAPK pathway alterations, most commonly KRAS , NRAS , and BRAF mutations, occur in approximately 50–60% of ovarian low-grade serous carcinomas (LGSCs). We sought to identify clinically translatable markers of MAPK pathway activation in LGSC samples. Differential gene expression a...

The pan-tumor landscape, allelic status, and genomic complexity of SMARCA4 alterations

PURPOSE: The clinical implications of distinct SMARCA4 alteration classes remain incompletely defined. We performed a pan-cancer analysis to characterize SMARCA4 mutation classes and their associations with allelic status, genomic context, and therapeutic outcomes. PATIENTS AND M...