Pichayanoot Rotkrua

Structure-Guided Optimization of a LipL32-Targeting DNA Aptamer through Molecular Dynamics and Free-Energy Analysis

Abstract Accurate detection of leptospirosis requires high-affinity recognition of the conserved LipL32 biomarker. Although LipL32-targeting DNA aptamers have been identified through systematic evolution of ligands by exponential enrichment (SELEX), the molecular basis of their t...