Phinea Z. Romero

Amyloid beta plaque pathology induces chemosensory deficits and increases apnoeas in the 5XFAD mouse model of Alzheimer's disease

Abstract Sleep disordered breathing (SDB) commonly co‐presents with other ventilatory impairments in patients with Alzheimer's disease (AD). Typically reported as either obstructive (OSA) or complex sleep apnoea in AD patients, SDB results in repeated bouts of hypoxia and hyperca...

Pericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model

Abstract Cerebral hemodynamic dysfunction is a key driver of unhealthy brain aging. Impaired microcirculatory reactivity leads to uneven perfusion, rendering deeper brain regions more vulnerable and thereby contributing to cognitive decline. Yet how capillaries contribute to thes...