Philippe Barthélémy

Self-assembled nucleolipid G-quadruplexes act as multitarget decoys for oncogene suppression in pancreatic cancer

Abstract KRAS mutations drive multiple cancers and represent an important therapeutic target, together with other oncogenic regulators such as MYC , KIT , and BCL2 that are critically involved in pancreatic cancer. Here we describe a novel therapeutic strategy based on stable nuc...

Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides

Using a set of spectroscopic experiments, we investigated the binding of Cu 2+ and Cu + to a comprehensive series of nucleic acid‐related molecules, ranging from individual nucleobases to oligonucleotides up to six nucleotides in length. We demonstrate the selective binding of Cu...