Philipp Germer

S -Adenosyl- l -homocysteine Hydrolase Side Reactivity Enables Biocatalytic Access to 4′,5′-Dehydro Nucleosides as Nucleoside Drug Precursors

Abstract S-Adenosyl-l-homocysteine hydrolase (SAHH) reversibly cleaves S-adenosyl-l-homocysteine (SAH) into adenosine and l-homocysteine, regulating the cellular potential to perform S-adenosyl-l-methionine (SAM)-dependent methylation of DNA, RNA, proteins, and small molecules. A...