Peter V.E. McClintock

A phenomenological multiscale framework for orientational interactions and viscoelasticity in migrating epithelial monolayer

Collective migration of epithelial monolayers emerges from the interplay between mechanical interactions and biochemical signalling on the cellular scale. Here, we provide a phenomenological mechanobiological framework with constitutive interpretation linking microscopic orientat...

Piezo1 footprint nanoarchitecture: from individual channels to collective behaviour and from outward to inward curvature

Piezo1 acts as a key architect of the cell membrane, generating a curved nanodome that extends beyond the protein trimer itself. Although Piezo1 intrinsically favours an outward (convex) membrane footprint, recent high-resolution studies have revealed that clustered channels can...