Peter Paul De Deyn

TNFR2 agonist treatment differentially affects neuropathology and neuroimmune responses in male and female 3xTg-AD mice

Neuroinflammation is a central contributor to Alzheimer’s disease (AD) progression, with tumor necrosis factor alpha (TNF-α) playing a key regulatory role as a master pro-inflammatory cytokine. While therapies inhibiting total TNF-α have produced inconsistent results and adverse...