Peter M. Mbelele

Distinct transcriptional remodeling of immune and metabolic pathways in severe undernutrition during latent tuberculosis infection does not consistently predict tuberculosis progression across independent cohorts

Background: Undernutrition increases tuberculosis (TB) risk, but whether severe undernutrition during latent TB infection (LTBI) produces blood transcriptional changes that resemble active disease or identify future TB remains unclear. Methods: We reanalyzed whole-blood RNA seque...

A scoping review of antimicrobial resistance surveillance and its use in guiding empirical therapy and antimicrobial stewardship in Tanzania

Antimicrobial resistance (AMR) is an increasing public health challenge in Tanzania, threatening effective antibiotic therapy and complicating management of bacterial infections. Although national and sentinel surveillance systems generate important resistance data, evidence on t...