Peter D. Katsikis

Integrated transcriptomic and proteomic analysis reveals innate and adaptive immune dynamics in systemic autoinflammatory diseases

Systemic autoinflammatory diseases (SAIDs) are a diverse group of rare disorders with partially overlapping clinical features. However, their genetic makeup and treatment responses vary widely. Although inflammasome dysregulation is central to many SAIDs, recent studies suggest t...

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study

BACKGROUND: Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), persistent viral reservoirs prevent cure and necessitate lifelong treatment. While short-term dynamics of HIV-1 rebound following treatment interruption have been extensively studied,...