Pengfei Dai

Preclinical Evaluation of 68Ga-Labeled Heterodimers for Dual Integrin αvβ3 and PARP1-Targeted Tumor Imaging

Abstract Tumor heterogeneity limits the diagnostic performance of molecular imaging probes targeting a single biomarker. Here, we report the design, synthesis, and preclinical evaluation of 68Ga-labelled heterodimeric radiotracers co-targeting integrin αvβ3 and poly(ADP-ribose) p...

Shared‐Output Aptamer‐Gated DNA Nanodevices Program NbaSPARDA Trans‐Cleavage for Metabolite and Drug Sensing

ABSTRACT Routing chemically distinct small‐molecule aptamers into a common nuclease trans‐cleavage pathway is constrained by the target‐specific output handles of conventional structure‐switching aptamers (SSAs). Shared‐output aptamer‐gated DNA nanodevices are designed so that re...