Peng-Yi Wu

Native Mass Spectrometry Reveals Ligand-Specific Conformational Heterogeneity of the β1-Adrenergic Receptor Using Nanobody Probes

Abstract G protein-coupled receptors (GPCRs) are central physiological signal transducers and represent a primary class of therapeutic targets. While emerging evidence highlights a critical link between ligand-induced receptor conformations and pharmacological outcomes, the struc...