Peng Liu

Catalytic Redox-Neutral Decarboxylative Aromatization via Transfer Dehydrogenation

Abstract Arenes are fundamental structural motifs in organic molecules; therefore, methods for introducing aromatic rings are of broad importance. Traditional approaches that install arenes early followed by postfunctionalization sometimes struggle to achieve diverse substitution...

Radical Markovnikov Hydroboration of Unactivated Terminal Alkenes With HBaza‐Type Hydroborane via a Triple Catalysis

ABSTRACT Organoboron compounds are versatile building blocks for C─C and C–heteroatom bond formation, with broad applications in drug discovery and materials science. Hydroboration of alkenes with hydroboranes is a reliable route to access organoboron compoundsssssss, yet the Mar...

Isolating Ligand Steric Effects on Metal Ion Reduction and Gold Nanoparticle Formation Pathways Using Au(I)–Phosphine Complexes

Abstract Steric effects are widely used to control molecular reactivity, yet their role in nanoparticle (NP) synthesis remains difficult to isolate and leverage because changes in ligand structure often alter both precursor electronic structure and resulting reduction thermodynam...

Diastereo- and Enantioselective Photobiocatalytic α-Alkylation of α-Heteroaryl Amines Enabled by Pyridoxal Photochemistry

Abstract We report a photobiocatalytic system for the enantio- and diastereoselective α-alkylation of α-heteroaryl amines, a largely underexplored class of synthetically valuable non-native amine donors. Evaluation and directed evolution of thermophilic threonine aldolases, enabl...

Rationally DesignedMalonate-Derived Ligands EnableCopper-Catalyzed C–N Coupling via a Cu(I)/Cu(III) Mechanism

Abstract A class of sterically decorated, malonamide ligands has been developed to enable copper-catalyzed C–N coupling for the synthesis of pharmaceutically relevant heterocycles. This methodology facilitates the efficient coupling of aryl and heteroaryl bromides with a broad ra...