Peng Cao

Cynarin Targets Host CX3CR1 for Dual-Action Prophylaxis against RSV Infection and Pulmonary Pathology

Abstract Safe, small-molecule prophylactic agents against respiratory syncytial virus (RSV) are critically lacking. Here, we identify Cynarin, an artichoke-derived dietary polyphenol, as a micromolar affinity CX3CR1 antagonist. Mechanistically, Cynarin confers dual-action protect...

Oral Nano-Oxygen Modulates the Intestinal HIF-2α/NEU3/Ceramide Axis to Mitigate NAFLD

Abstract The intestinal hypoxia-inducible factor-2α (HIF-2α)/neuraminidase 3 (NEU3)/ceramide axis has emerged as an important regulator of gut–liver communication in nonalcoholic fatty liver disease (NAFLD). However, systemic inhibition of HIF-2α may interfere with hepatic glucos...