Pei‐Pei Xie

Catalytic Redox-Neutral Decarboxylative Aromatization via Transfer Dehydrogenation

Abstract Arenes are fundamental structural motifs in organic molecules; therefore, methods for introducing aromatic rings are of broad importance. Traditional approaches that install arenes early followed by postfunctionalization sometimes struggle to achieve diverse substitution...

Enantioselective Synthesis of Azahelicenes via Rh-Catalyzed C–H Functionalization of 6-Hydroxyisoquinoline Derivatives with Alkynes

Abstract Herein, we report an asymmetric C–H functionalization of 6-hydroxyisoquinoline derivatives and annulation with internal alkynes. The reaction is catalyzed by a chiral cyclopentadienyl (Cp)-Rh complex in combination with a modified chiral amino acid. A series of azahelice...

Rationally DesignedMalonate-Derived Ligands EnableCopper-Catalyzed C–N Coupling via a Cu(I)/Cu(III) Mechanism

Abstract A class of sterically decorated, malonamide ligands has been developed to enable copper-catalyzed C–N coupling for the synthesis of pharmaceutically relevant heterocycles. This methodology facilitates the efficient coupling of aryl and heteroaryl bromides with a broad ra...