Pei‐Pei Xie

Rationally DesignedMalonate-Derived Ligands EnableCopper-Catalyzed C–N Coupling via a Cu(I)/Cu(III) Mechanism

Abstract A class of sterically decorated, malonamide ligands has been developed to enable copper-catalyzed C–N coupling for the synthesis of pharmaceutically relevant heterocycles. This methodology facilitates the efficient coupling of aryl and heteroaryl bromides with a broad ra...