Pei Tang

Iridium-Catalyzed Asymmetric Hydrogenation of Pyridazine Salts under Batch and Flow

Abstract Herein, we report an [Ir(COD)Cl]2/(R)-SunPhos-catalyzed asymmetric hydrogenation of pyridazine salts to construct chiral hexahydropyridazines. The reaction tolerates a wide range of substituents, delivering products in up to 97% yield with 97% ee under mild reaction cond...