Pedro Henrique Corteletti Manfio

Acidic StressInduces Proteomic Reprogramming andVirulence-Associated Adaptation in Paracoccidioides brasiliensis

Abstract Paracoccidioidomycosis (PCM) is a neglected systemic mycosis whose etiologic agents must adapt to acidic host niches such as phagolysosomes. Here, we used quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to define the response of Pa...