Pedro H Ayres-Galhardo

Substrate-bound structures of yeast ALA synthase reveal protein dynamics initiating heme biosynthesis

Heme is an essential prosthetic group involved in multiple biological processes in nearly all organisms. Heme biosynthesis is initiated by the pyridoxal 5′-phosphate–dependent enzyme aminolevulinic acid synthase (ALAS). Mutations in ALAS cause multiple hematological diseases. Des...