Pavel Ryšánek

Pharmacokinetics and immunomodulatory effects of selective orexin 1 receptor agonist OXA 17–33: PBMC responses, HPA axis activation, and outcomes in the collagen-induced arthritis model

Given the expanding clinical use of orexin-modulating drugs, this study investigated whether orexin agonism or antagonism influences inflammatory responses in vitro and in vivo. PBMCs stimulated with LPS or TNF were treated with orexin agonists or antagonists. In rats, pharmacoki...