Paul S. Freemont

Covalent linkage of the papillomavirus E2 DNA-binding domain reveals a soluble amyloid-like assembly pathway

Abstract Early soluble intermediates in amyloid formation are difficult to characterize because they are transient and obscured by competing insoluble aggregation. Here, we use scE2C, an engineered covalently linked version of the HPV16 E2 DNA-binding dimer, as a tractable model...

Navigating regulatory fragmentation in the convergence of synthetic biology, artificial intelligence, and automation

The convergence of synthetic biology, artificial intelligence (AI), and automation (SynBioxAI) creates research activities that simultaneously engage biosecurity, AI governance, export control, and data sovereignty frameworks – none of which are designed for convergent science. W...