Paul R. Walker

HMGB1 expression in CT26 murine cancer cells modulates the tumor microenvironment and limits local anti-tumor immunity

Abstract High mobility group box protein 1 (HMGB1) is a ubiquitous protein that has multiple functions in the nucleus and cytosol. Following release into the extracellular space, HMGB1 acts as a mediator of inflammation. HMGB1 is overexpressed in many cancers and has both oncogen...