Author
Paul M. Thompson
Recent research
- Health & MedicineOpen access
Abstract Bipolar disorder (BD) is a prevalent psychiatric condition characterized by marked clinical and neuroanatomical heterogeneity. Prior neuroimaging studies have used case-control comparisons yielding small to moderate effect sizes for group differences. Large and diverse s...
- BiologyOpen access
Charting brain structure in 22q11.2 deletion syndrome with clinical neuroimaging
Abstract Background 22q11.2 deletion syndrome (22q11DS) is a common microdeletion associated with widespread brain alterations and elevated risk for schizophrenia and other neuropsychiatric conditions. Prospective research studies often exclude individuals with severe cognitive i...
- BiologyOpen access
Sex-specific biological aging clocks across organs and omics
Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer’s disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex in...