Paul M. Dias

Short-Chain Fatty Acids as Endogenous Inhibitors of DPP-IV Enzyme: Implications in GLP-1 Stability and Metabolic Health

Abstract Dipeptidyl peptidase-IV (DPP-IV/CD26) is a circulating serine protease that rapidly degrades incretin hormones, including glucagon-like peptide-1 (GLP-1), limiting incretin activity and glucose homeostasis. Short-chain fatty acids (SCFAs), major gut microbiota-derived me...