Paul de Vos

Unsulfated secondary bile acids and structurally defined pectins modulate intestinal barrier responses under acute hyperglycemic conditions in intestinal epithelial co-cultures

The intestinal epithelial barrier maintains gut homeostasis and limits systemic inflammation. Barrier dysfunction is linked to metabolic disorders including diabetes, yet the combined effects of hyperglycemia, microbial metabolites, and dietary polysaccharides on epithelial integ...