Patrizia Fontana

Comparing YAPWW1 and TAZWW: Similar Binding Sites but Different Stability and Conformational Dynamics

The two paralogs YAP and TAZ act through TEAD transcription factors and bind PPxY motif proteins in the Hippo pathway via WW domains. YAP has up to two WW domains, whereas TAZ has one. Because YAPWW1 and TAZWW are the most similar in sequence, they can be considered as correspond...