Patrizia Borsotti

Bone marrow–derived thrombospondin-1 programs tumor cell dormancy via CD47–integrin αvβ3 axis

Dormant disseminated tumor cells are responsible for late metastatic relapses, a current clinical challenge. This study investigates the microenvironmental signals that maintain breast cancer cell quiescence in the bone marrow. 4T1.2-CVp27 cells, engineered to enable quiescence d...