Pathum Kossinna

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Genetic contributions to complex traits are often mediated through coordinated gene–gene interaction networks, yet most existing association frameworks focus on marginal single-gene effects and overlook higher-order dependency structures. Direct modeling of interactions remains c...

Lupus Double-Negative B Cells Harbor Expanded Somatic Mutations in Lymphoma-Relevant Pathways

Objectives Systemic lupus erythematosus (SLE) patients have a 2–7-fold increased risk of hematologic malignancies, particularly B-cell non-Hodgkin lymphoma (B-NHL).[1] Although germline susceptibility shared between SLE and B-NHL is minimal,[2] somatic evolution of autoreactive B...