Paris E. Grimaldi

Self-Catalyzed Transesterification Transforms Ionizable Amphiphilic Janus Dendrimers into Multicomponent Vectors and Generates Complex Design Strategies for mRNA Delivery

Abstract Genetic nanomedicine delivers nucleic acids by viral and synthetic vectors to produce drugs directly in the body’s own cells. Each approach presents relative advantages, but synthetic vectors are distinguished by their effectively unlimited synthetic capabilities. The le...