Parimal Kar

Integrating Gaussian Accelerated Molecular Dynamics, β-Variational Autoencoders, and Markov State Models Reveals the Activation Landscape of FGFR3 Kinase

Abstract Fibroblast growth factor receptor 3 (FGFR3) kinase plays a crucial role in cellular differentiation, proliferation, and skeletal development. Activation of the kinase domain through phosphorylation regulates the downstream signaling cascades, and its dysregulation leads...