Panupong Mahalapbutr

Anti-proliferative and anti-inflammatory potential of 2-chloro-3-((4-hydroxyphenyl)amino)naphthalene-1,4-dione through targeting TNF-α/IL-8 and NF-κB signaling in HCT116 cancer cells: a comprehensive in silico docking and in vitro study

Colorectal cancer (CRC) is closely associated with chronic inflammation, and the NF-κB pathway acts as a central regulator of the inflammatory response that promotes tumor progression. In this study, we examined the anticancer and anti-inflammatory potential of anilino-1,4-naphth...

Application of serum MUC4/MUC1 ratio for diagnosis of meningioma and glioblastoma

Background Meningiomas (MGs) are the most common primary brain tumors, arising from arachnoid cap cells within the meninges. There is currently no validated, clinically used serum marker for brain tumors; diagnosis still relies on imaging and histopathology/molecular testing of r...

Discovery of Bis-ThioureaDerivatives as Human DNATopoisomerase IIα Inhibitors with Potent Anticancer Effects

Abstract DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for...