Pang Yao

Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease

Abstract Tobacco smoking increases the risk of multiple diseases, but the biological mechanisms involved remain incompletely understood. Here we characterize smoking-related protein profiles to identify potentially causal biomarkers mediating smoking’s effects. In European-ancest...

Smoking, Exhaled Carbon Monoxide, and Risk of Parkinson Disease

Importance Smoking has been associated with lower risks of Parkinson disease (PD) in epidemiological studies, but the underlying mechanisms remain poorly elucidated. Objective To investigate the association of exhaled carbon monoxide (CO) with risk of PD. Design, Setting, and Par...

Proteomics in cardiology: research and practice

Despite recent advances in prevention and treatment, cardiovascular disease (CVD) remains a leading cause of premature death and disability globally, with a rising burden in many low- and middle-income countries. Several modifiable determinants of CVD are well-established (eg, sm...