Pamina M. Gorbach

Paradoxical relationships of interleukin-6 and tumor necrosis factor-alpha with methamphetamine use and body mass index

Abstract Background: Methamphetamine (MA) use and obesity are linked to inflammation and related comorbidities, yet their combined effects are poorly understood. We evaluated associations between MA use, body mass index (BMI), and systemic inflammation. Methods: We analyzed data...

Comparison of oral and gut microbiome highlights the role of oral bacteria in systemic inflammation in HIV

ABSTRACT Background Chronic HIV-1 infection is associated with increased inflammation-related comorbidities, despite effective viral suppression with antiretroviral therapy. While the role of the gut microbiome in inflammation is well-studied, the contribution of the oral microbi...

Associations between substance use by type and HIV viral suppression across multiple cohorts in the US

Substance use among people with HIV (PWH) represents an important obstacle to further reductions in HIV transmission. Using data from a diverse collection of five studies including people with HIV in care and those in community cohorts, we report results for analyses of the assoc...