Osvaldo Gutiérrez

Regio- and Enantioselective Functionalization of Gaseous Alkanes via Nickel-Catalyzed Alkene Dicarbofunctionalization

Abstract The regio- and enantioselective functionalization of gaseous alkanes remains an unsolved challenge in organic synthesis. Here, we report a general strategy for the asymmetric three-component dicarbofunctionalization of alkenes using readily available gaseous alkanes, inc...

Redox-Dependent Lipophilicity of Phenazine Metabolites Is Modulated by Intramolecular Hydrogen Bonds and Controls Their Biological Distribution

Abstract Phenazines are redox-active microbial metabolites produced and secreted in diverse ecological contexts from soils to chronic infections. Phenazines can function variously as antibiotics, extracellular electron shuttles, and nutrient scavengers. Key to understanding the i...