Ossia M. Eichhoff

FDX1-independent non-canonical cuproptosis establishes a parallel mitochondria-centric death program

Abstract Objectives Copper is an essential redox cofactor required for mitochondrial respiration and antioxidant defense, yet its dysregulation creates a therapeutic vulnerability that can be exploited by copper active agents. Elesclomol and neocuproine are two potent copper acti...