Oskar Hansson

Cognitive impairment, medial temporal lobe changes, and fluid biomarkers of Alzheimer’s disease and neurodegeneration following herpes simplex virus type 1 encephalitis

Abstract Background Herpesvirus encephalitis is a severe brain infection, in adults most often caused by herpes simplex virus type 1 (HSV-1). It predominantly affects the medial temporal lobes (MTL), which are critical for memory functions. Links have been discussed between herpe...

Translational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins

In Alzheimer’s disease (AD), activation of the mechanistic target of rapamycin (mTOR) pathway promotes microglial neuroprotective functions by engaging multiple cell receptors. However, the relevant downstream effectors are not fully understood. mTOR complex 1 (mTORC1) promotes m...