Onno Kranenburg

Site-dependent treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance

In colorectal cancer (CRC), tumor-infiltrating regulatory T (Treg) cells suppress anti-tumor immunity, promoting immune evasion and tumor progression. Effective therapies require selectively targeting tumor-infiltrating Treg (TI-Treg) cells while preserving systemic Treg cells, n...