Omid Bavi

Localized thermal perturbation alters lipid bilayer structure and daunorubicin interactions in MscL-containing membrane systems

Cancer poses one of the major challenges to human mortality; however, conventional chemotherapy is limited by off-target toxicity and non-specific drug distribution. Stimuli-responsive nanocarriers have been explored to address these limitations and enhance targeted therapeutic e...

Opening threshold and kinetics of the MscL mechanosensitive channel are regulated by its periplasmic loop

Abstract Mechanosensitive (MS) channels are membrane proteins that respond to mechanical stimuli and are essential across prokaryotic and eukaryotic organisms. The E. coli mechanosensitive channel of large conductance (MscL) provides a powerful model for dissecting protein–lipid...