Omer khiyam

Age-associated transcriptomic heterogeneity in acute myeloid leukaemia: Evidence for mitochondrial metabolic rewiring and suppressed erythroid differentiation in older patients

Background: The incidence and clinical aggressiveness of acute myeloid leukaemia (AML) both increase with patient age, yet the transcriptional programmes that distinguish older from younger AML remain incompletely defined. We characterised age-associated gene expression patterns...