Ömer Buhşem

In silico AI-guided de novo design of S1PR1-targeting ligands from a siponimod scaffold for angiogenesis and fat-cartilage graft survival

Fat cartilage graft survival is frequently limited by insufficient early vascularization, resulting in ischemia and partial tissue loss. Sphingosine-1-phosphate receptor 1 (S1PR1) is a key regulator of endothelial barrier integrity, vascular maturation, and controlled angiogenic...