Oliver Gould

Decoding the regulatory programs governing glioblastoma plasticity

Abstract Glioblastoma is incurable and resistant to therapy despite genomic stability under treatment 1–8 , suggesting that non-genetic cellular plasticity is a central driver of progression. Whether such plasticity reflects stochastic state switching or is governed by predictabl...

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Abstract Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single...