Ole Fröbert

Changes in circulating biomarkers in symptomatic atrial fibrillation from before to one day after catheter ablation

Abstract Atrial fibrillation (AF) causes debilitating symptoms in some patients, whereas others remain asymptomatic; the biological basis remains unclear. In this prospective case–control study, we investigated whether circulating biomarkers were associated with symptom burden, d...

Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction

Abstract Aims Invasive management and intensive antithrombotic regimens have decreased ischemic risk after myocardial infarction (MI) at the cost of more bleeding. Of particular concern is upper gastrointestinal bleeding (UGIB), which is both common and preventable, yet not well...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...