Nuno A. T. C. Fernandes

A deep neural network-enhanced multi-scale coupled model of patient-specific acoustic wave propagation for mechanotransduction stimulation of healthy and osteoarthritic knee articular cartilage

Abstract This study presents a multi-scale computational framework to quantify how externally applied acoustic waves propagate through the knee joint and induce mechanotransductive strain at the level of the chondrocyte nucleus. Patient-specific knee geometries ( n = 8) were used...