Norifumi Iseda

Nuclear Pan‐Lysine Lactylation Immunoreactivity Is Associated With Poor Prognosis in Intrahepatic Cholangiocarcinoma

AIM: Lysine lactylation (Kla) links cellular metabolism to gene regulation, but its significance in intrahepatic cholangiocarcinoma (ICC) remains unclear. METHODS: Nuclear pan-Kla immunoreactivity was evaluated in 118 patients who underwent curative-intent resection for ICC. Asso...

Spatiotemporal dynamics of the tumor microenvironment in hepatocellular carcinoma during combination immunotherapy

Background: Atezolizumab plus bevacizumab (ATZ/BEV) is a standard first-line therapy for advanced hepatocellular carcinoma (HCC); however, many patients do not achieve meaningful tumor regression. The temporal and spatial immune remodeling associated with ATZ/BEV remains poorly u...