Norbert Frey

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

BACKGROUND AND PURPOSE: Myeloid cell leukaemia-1 (MCL-1) is an essential anti-apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL-1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardioto...